In the first part of this series we discussed one of the causes of Dog Skin Cancer, which are Environmental Carcinogens. You may reach that article by clicking this link.

The Causes of Dog Skin Cancer, Part 1: Environmental Carcinogens

Skin cancer may occur when mast cells are chronically or frequently activated by allergic reactions brought about by environmental carcinogens or genetic factors

We will now discuss the 2nd cause of Dog Skin Cancer, which are the Genetic Factors.

Genetic factors can be either Inherited Genetic Defects, or Aqcuired Genetic Defects. It was stated in the previous article that carcinogens more likely target older dogs, but genetic contributors of cancer have been observed to affect mostly the young.

Inherited Genetic defects mean that if your dog comes from a family that has a history of cancer, then it runs a higher risk of developing the same illness. Some breeds are more vulnerable to inherited skin cancer than others, and these are:

Boxers
Schnauzers
Boston Terriers
Golden Labrador Retrievers
Pugs
Beagles

Aquired Genetic Defects or Somatic Mutations are not inherited; rather they occur during vitro development. When a dog develops cancer at an early age without a case of cancer in their family history, it may be an indication that the cancer was acquired due to chromosomal mutation.

Other contributors to cancer aside from carcinogens and genetic defects are obesity, vaccinations, immune system problems, and hormonal factors.

Skin cancer may occur when mast cells are chronically or frequently activated by allergic reactions brought about by environmental carcinogens or genetic factors. This is when antibodies bind with mast cells and release reactive agents such as histamines, heparin, enzymes, and cytokines.